Craft the Cure
Irreversibly inhibits COX-1 and COX-2 enzymes, blocking prostaglandin and thromboxane A2 synthesis. Reduces platelet aggregation and inflammation.
Activates AMP-kinase, suppressing hepatic glucose production. Improves insulin sensitivity in peripheral tissues. May inhibit mitochondrial complex I.
Intercalates into DNA, inhibits topoisomerase II, and generates free radicals causing DNA damage. Triggers apoptosis in rapidly dividing cells.
Binds penicillin-binding proteins (PBPs), inhibiting transpeptidase-mediated cross-linking of peptidoglycan cell walls. Causes osmotic lysis of bacteria.
Agonist at mu-opioid receptors in the CNS and periphery. Inhibits ascending pain pathways, alters pain perception and emotional response to pain.
Modulates NF-kB, COX-2, and multiple inflammatory cytokines (TNF-alpha, IL-6). Exhibits antioxidant properties via Nrf2 pathway activation.
Activates SIRT1 (sirtuin 1) deacetylase, modulating cellular stress response and mitochondrial biogenesis. Inhibits NF-kB inflammatory pathway.
Modulates endocannabinoid system without direct CB1 binding. Activates 5-HT1A serotonin receptors, TRPV1 pain receptors, and inhibits FAAH enzyme.
Potent flavonoid antioxidant that inhibits lipid peroxidation, scavenges free radicals, chelates metal ions. Inhibits inflammatory enzymes LOX and COX.
Inhibits mTOR (mechanistic target of rapamycin) complex 1, suppressing cell growth, proliferation, and metabolism. Promotes autophagy and extends cellular lifespan.
Reversibly inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis. Decreases inflammation, pain, and fever through peripheral and central mechanisms.
Extended-spectrum penicillin that inhibits bacterial cell wall synthesis. Better oral absorption than ampicillin. Effective against many gram-positive and some gram-negative bacteria.
ACE inhibitor that blocks conversion of angiotensin I to angiotensin II. Reduces aldosterone secretion, decreases preload/afterload, prevents cardiac remodeling.
Proton pump inhibitor (PPI) that irreversibly binds H+/K+ ATPase in parietal cells, blocking the final step of gastric acid secretion. Raises gastric pH for 24+ hours.
Synthetic T4 (thyroxine) that converts to active T3 in peripheral tissues. Binds nuclear thyroid receptors to regulate metabolic rate, growth, and development.
Add at least 2 compounds to simulate